2010 Mentored Young Investigator Recipient
Kate Finlayson Memorial Research Grant
TITLE: Post-Doctoral Fellow
INSTITUTION: University of California, San Diego, School of Medicine
This award was made possible through the generous support of Team Hydro.
Dr. Podvin is a post-doctoral fellow at the University of California, San Diego. She received a B.A. from Wellesley College in Biochemistry and a PhD in pharmacology and biomedical neuroscience from Boston University.
STUDY TITLE: Augurin is a novel choroid plexus-derived peptide hormone that regulates CSF formation by controlling epithelial cell homeostasis
MENTOR: Andrew Baird, PhD
The study hypothesized that the peptide hormone, augurin, is produced and secreted by the choroid plexus epithelium, is a ligand for an unknown receptor and has a critical function in CSF fluid homeostatsis. If proven, researchers predict that augurin can be manipulated pharmacologically to treat hydrocephalus.
Neuroscience, Pharmacology, Medical Neurosciences, Neurobiology and Brain Physiology, Neuropharmacology
Selected hydrocephalus-related articles
Dang X, Podvin S, Coimbra R, Eliceiri B, Baird A.
Cell-specific processing and release of the hormone-like precursor and candidate tumor suppressor gene product, Ecrg4.
Cell Tissue Res. 2012 Jun;348(3):505-14.
Podvin S, Gonzalez AM, Miller MC, Dang X, Botfield H, Donahue JE, Kurabi A, Boissaud-Cooke M, Rossi R, Leadbeater WE, Johanson CE, Coimbra R, Stopa EG, Eliceiri BP, Baird A.
Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury.
PLoS One. 2011;6(9):e24609.
Gonzalez AM, Leadbeater W, Podvin S, Borboa A, Burg M, Sawada R, Rayner J, Sims K, Terasaki T, Johanson C, Stopa E, Eliceiri B, Baird A.
Epidermal growth factor targeting of bacteriophage to the choroid plexus for gene delivery to the central nervous system via cerebrospinal fluid.
Brain Res. 2010 Nov 4;1359:1-13.
Gonzalez AM, Podvin S, Lin SY, Miller MC, Botfield H, Leadbeater WE, Roberton A, Dang X, Knowling SE, Cardenas-Galindo E, Donahue JE, Stopa EG, Johanson CE, Coimbra R, Eliceiri BP, Baird A.
Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury.
Fluids Barriers CNS. 2011 Jan 18;8(1):6.
Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR.
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17.
Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19796-801.
Duce JA, Podvin S, Hollander W, Kipling D, Rosene DL, Abraham CR.
Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey.
Glia. 2008 Jan 1;56(1):106-17.