Join a Clinical Trial
Enrolling in clinical research trials is one way our community can become active participants in the quest to improve outcomes and find a cure for hydrocephalus. On this page, you can learn about ongoing trials.
Clinical Trials
Genetic Causes of Congenital Hydrocephalus
Enrolling NOW
Lead Investigator: Kristopher Kahle, MD, PhD
Location: Yale University, The Anlyan Center, 300 Cedar Street, Rm S311, New Haven, CT 06519
Recruiting: locally, regionally, and nationally
Eligibility: Families affected by congenital (developmental) hydrocephalus
The Placebo-controlled Efficacy of iNPH Shunting (PENS) Trial
Enrolling NOW
Lead Investigator: Mark Luciano, MD, PhD
Location: Sites across the country with the main site at Johns Hopkins Medicine, Baltimore, MD
Recruiting: locally, regionally, and nationally
Eligibility: Adults aged 60 and older who have idiopathic (unknown cause) Normal Pressure Hydrocephalus (iNPH) and plan to have a shunt placed
How to participate: Please email Kallan Dirmeyer at kdirmey1@jh.edu
Safety of Combined Therapy with Erythropoietin and Melatonin for Preterm Infants with Intraventricular Hemorrhage (SCEMPI)
Enrolling NOW
Lead Investigator: Shenandoah (Dody) Robinson, MD
Location: Johns Hopkins Children’s Center and Johns Hopkins Bayview Medical Center Neonatal Intensive Care Units (NICUs), Baltimore, MD
Recruiting: within the Johns Hopkins NICUs or from a regional NICU (NICU transfer requests to Johns Hopkins must be initiated by the neonatologist in the regional NICU)
Eligibility: Babies born prematurely after 22 weeks and before 32 weeks gestation and that are less than 21 days old. These babies have had a severe brain bleed seen on head ultrasound that was done within the past 18 days. For this clinical trial, a significant bleed is defined as at least a grade II IVH on at least one side of the brain.
A Randomized Controlled Trial of Anterior versus Posterior Entry Site for CSF Shunt Insertion
Enrollment is now COMPLETE
Lead Investigator: William Whitehead, MD, Texas Children’s Hospital
Location: HCRN Centers in the United States and Canada
Eligibility: Children younger than 18 years of age and getting their first permanent shunt
Patient Registries
HAPPIER™ – HA Patient Powered Registry
Join the FIRST Hydrocephalus Patient Registry and help accelerate hydrocephalus research.
The Patient Registry is an online database created for our community to share your experience living with hydrocephalus. By sharing your experience, you’re giving researchers access to important data that can lead to discoveries in underlying causes of the condition, intervention strategies for preventing the condition, improvements in diagnosis, and/or alternative treatments.
Lead Investigator: Monica Chau, PhD
Recruiting: Worldwide
Eligibility: Adults older than 18 years of age or parents/caregivers
AHCRN Core Data Project
Open to patients at participating AHCRN Centers
Lead Investigator: Mark Hamilton, MD, University of Calgary
Location: AHCRN Centers in United States and Canada
Eligibility: Adults older than 18 years of age
HCRN Core Data Project
Open to patients at participating HCRN Centers
Lead Investigator: Jay Riva-Cambrin, MD, University of Utah
Location: HCRN Centers in United States and Canada
Eligibility: Children younger than 18 years of age
HCRN Core Data Project: Characterizing Patient Populations within the HCRN: Shunt Infection Registry
Open to patients at participating HCRN Centers
Lead Investigator: Tamara Simon, MD, Seattle Children’s Hospital
Location: HCRN Centers in United States and Canada
Eligibility: Children younger than 18 years of age
HCRN Core Data Project: Characterizing Patient Populations within the HCRN: Endoscopic Third Ventriculostomy Registry
Open to patients at participating HCRN Centers
Lead Investigator: Abhaya Kulkarni, MD, The Hospital for Sick Children
Location: HCRN Centers in United States and Canada
Eligibility: Children younger than 18 years of age
To search for more hydrocephalus clinical trials visit clinicaltrials.gov