Timothy Vogel, MD

2013 Established Investigator

INSTITUTION: Hackensack University Medical Center

STUDY TITLE: The role of neural progenitor cells in the development of neonatal hydrocephalus

Overview

Dr. Vogel is a pediatric neurosurgeon and an Assistant Professor of pediatric neurosurgery and developmental biology at Cincinnati Children’s Hospital Medical Center.  He holds a BA in chemistry from Princeton University and an MD from Columbia University College of Physicians and Surgeons. Dr. Vogel received a CSF Production, Flow, and Regulation, Therapeutics and Diagnostics award in 2013 for his study, The role of neural progenitor cells in the development of neonatal hydrocephalus.

His research hypothesizes that abnormal signaling through primary cilia during neural progenitor cell (NPC) development contributes to the development of neonatal hydrocephalus. Recently, it has been shown that mutations of genes that disrupt cilia in the ventricles lead to the development of hydrocephalus. These findings demonstrate that brain cilia aid in the normal development of NPCs, suggesting a link between the ventricles and brain development. The close proximity of NPCs to the ventricles suggests that these cells maintain the size of the ventricles.

Publications 

Selected hydrocephalus-related articles

Vogel TW, Bahuleyan B, Robinson S, Cohen AR.
The role of endoscopic third ventriculostomy in the treatment of hydrocephalus.
J Neurosurg Pediatr. 12(1):54-61. 2013

Vogel TW, Manjila S, Cohen AR.
Novel neurodevelopmental disorder in the case of a giant occipitoparietal meningoencephalocele.
J Neurosurg Pediatr. 10(1):25-9. 2012

Carter CS, Vogel TW, Zhang Q, Seo S, Swiderski RE, Moninger TO, Cassell MD, Thedens DR, Keppler-Noreuil KM, Nopoulos P, Nishimura DY, Searby CC, Bugge K, Sheffield VC.
Abnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model.
Nat Med. Dec;18(12):1797-804. 2012

Vogel TW, Carter CS, Abode-Iyamah K, Zhang Q, Robinson S.
The role of primary cilia in the pathophysiology of neural tube defects.
Neurosurg Focus. Oct;33(4):E2. 2012

Dlouhy BJ, Viljoen SV, Kung DK, Vogel TW, Granner MA, Howard MA 3rd, Kawasaki H.
Vagus nerve stimulation after lead revision.
Neurosurg Focus. 32(3):E11. 2012

Vogel TW, Menezes AH.
Natural history and management of cervical spine disease in chondrodysplasia punctata and coumarin embryopathy
Childs Nerv Syst. 28(4):609-19. 2012

Bahuleyan B, Vogel TW, Robinson S, Cohen AR.
Endoscopic total corpus callosotomy: cadaveric demonstration of a new approach.
Pediatr Neurosurg. 47(6):455-60. 2011

 

 

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