Hydrocephalus  Research Workshop

8am Breakfast

8:20am Opening and welcoming remarks

Francesco Mangano, DO, Cincinnati Children's Hospital Medical Center

Diana Gray, MA, Hydrocephalus Association

Monica Chau, PhD, Hydrocephalus Association

Session: Creating scientific consensus in the field

What are the ideal animal models and techniques to induce hydrocephalus?

9:25am Moderator: Pat McAllister, PhD, Washington University in St. Louis; Introduction to the round tables

9:30am Marc del Bigio, MD, PhD, University of Manitoba; Animal models of hydrocephalus: what is their translational utility for development of therapies?

9:45am Acquired hydrocephalus models overviews:

Pat McAllister, PhD, Washington University in St. Louis; Kaolin-induced hydrocephalus models

Jose Peiro, MD, PhD, Cincinnati Children's Hospital Medical Center; Fetal intracisternal Bioglue for a new model of obstructive hydrocephalus in large animal research

Lauren Jantzie, PhD, Johns Hopkins University; The essential role of inflammation in modeling PHHP secondary to IVH

Brandon Miller, MD, PhD, UTHealth Houston; Using blood vs. hemoglobin for IVH research

10:15am Consensus building: open discussion

10:40am Break

10:55am Genetic models overviews:

June Goto, PhD, Cincinnati Children's Hospital Medical Center; Genetic insights into models of congenital hydrocephalus

Mark Johnson, MD, PhD, UMass Memorial Health; Decoding iNPH: Mechanistic Insights from Genetically Engineered Mice

11:10am Consensus building: open discussion

Endpoint measurements in hydrocephalus studies

Moderator: Bonnie Blazer Yost, PhD, IUPUI

11:25 am Endpoint measurements

Harriet Kamendi, PhD, Kandih BioScience – FDA toxicology expectations

Charles V. Vorhees, PhD, University of Cincinnati - Behavioral testing paradigms as hydrocephalus endpoint measures

Diana Lindquist, PhD, Cincinnati Children's Hospital Medical Center - Translating MRI to the preclinical realm: advanced rodent neuroimaging for the evaluation of hydrocephalus

11:45am Consensus building: open discussion

12:10pm  Lunch

Patient perspective: What motivates patients to participate in clinical studies?

1:10pm Moderator: Samantha Lanjewar, PhD, Hydrocephalus Association

Denise Berman, MA

Alejandro Rojas, PhD, Ananke Therapeutics

Lynn Beirl, BS, Flourishing in Mid-Life Women’s Hydrocephalus Group

Lessons from current and past clinical trials

Moderator: David Limbrick, MD, PhD, Virginia Commonwealth University

1:50pm David Limbrick, MD, PhD, Virginia Commonwealth University - ESTHI trial and lessons learned

2:15pm Francesco Mangano, DO, Cincinnati Children's Hospital Medical Center; Governance in clinical trials: DSMB

2:30pm Robin Ohls, MD, PhD, University of Utah - Phase I-III trials in preterm infants using Darbepoetin

2:55pm Bonnie Blazer Yost, PhD, IUPUI – Perspectives from kidney disease clinical trials and navigating the patent process for hydrocephalus treatment

3:20 pm Break

3:35pm Shenandoah (Dody) Robinson, MD, Johns Hopkins University - Overcoming regulatory barriers on the way to Phase I: A clinical trial of EPO+MLT in preterm infants with severe IVH

4pm Mark Luciano, MD, Johns Hopkins University - Minority access to Neurosurgery: iNPH as a case study

Industry perspective

Moderator: Francesco Mangano, DO

4:25 pm Mike McBreen, Integra LifeSciences- How we partner to help patients: an industry perspective

Synthesis discussion

Moderator: Lauren Jantzie, PhD

5pm Topic: How can we better design preclinical trials with a focus towards clinical translation?

5:20pm End of program day

6:30pm Group dinner (by invitation only), hosted by Integra LifeSciences

Via Vite Ristorante

520 Vine Street

Cincinnati, OH 45202

(513) 721-8483