Hydrocephalus Association & Rudi Schulte Research Institute Workshop
Honoring the Legacy of Dr. Michael Pollay
Sept 27-29, 2023
Developing Non-Invasive Hydrocephalus Therapies: Molecular and Cellular Targets
Event by invitation only
Presented By:
Session Topics:
- Translational and clinical research in hydrocephalus
- Navigating the clinical trials process: guidance & challenges
- Identifying targets in big data and using artificial intelligence for research
- Funders panel
When:
September 27-29, 2023
Where:
Le Meridien Dallas, Stoneleigh
Uptown Dallas
2927 Maple Avenue
Dallas, TX 75201
Phone: 214-871-7111
Hotel: The upcoming workshop will take place at Le Meridien, Stoneleigh in uptown Dallas. Hydrocephalus Association will take care of booking the rooms, so there's no need to contact the hotel to make reservations.
We are pleased to inform you that accommodations at Le Meridien, Stoneleigh hotel will be covered for the evenings of September 27th and 28th, 2023. If you wish to extend your stay, kindly inform us and we will assist you with the arrangements. Please note that our workshop venue is located at the Stoneleigh property and not at the Le Meridien Galleria.
Flights: There are two major airports in Dallas, DFW and DAL:
Dallas/Ft. Worth airport (DFW)- 19 miles from hotel
Dallas Love Field airport (DAL) - 4 miles from hotel. Smaller airport serving 3 airlines: Alaska, Southwest, Delta.
Travel Reimbursements: We will be able to cover hotel accommodations, incidental costs, as well as $450 for domestic flights/$650 for international flights. Save all of your receipts to submit after the workshop.
Sample travel itinerary:
9/27- Day 1, arrive in Dallas, program starts at 2pm
9/28- Day 2
9/29- Day 3, program ends in the afternoon, depart Dallas
Workshop Program
All program times are in Central Time (CT)
Wednesday, September 27
Theme: Identifying Hydrocephalus Targets Using Big Data & Machine Learning
- Welcome and introductions
Speakers: Diana Gray, MA, Gordon McComb, MD, Monica Chau, PhD
2:15 PM
A. BIG DATA
Moderator: Pat McAllister, PhD
- The Choroid Plexus Secretome and its Contributions to Myelination
Speaker: Alexandra Hochstetler, PhD
2:55PM - Leveraging Targeted and Untargeted Metabolomics to Characterize Embryonic CSF During Inflammation
Speaker: Boryana Petrova, PhD
3:20PM - Break | 3:50 PM
A. MACHINE LEARNING
Moderator: Pat McAllister, PhD
- From Data to Decision: A Pragmatic Guide to Machine Learning in Hydrocephalus Research
Speaker: Daniel Harris, MS
4:20 PM - Automated Identification of Normal Pressure Hydrocephalus on Imaging: Current Research Datasets
Speaker: Kevin King, MD
4:45 PM - Machine Learning and RNAseq in NPH
Speaker: Maria Grazia Ruocco, PhD
5:10 PM
B. FUTURE DIRECTIONS
- Synthesis Discussion
Moderator: Kevin King, MD
5:40 PM - End of program, Day 1
6:20 PM - Welcome Reception
7:30 - 9:30 PM
7:30-9:30 PM | Welcome Reception at Hotel Venue (Le Meridien, Stoneleigh), Terrace Ballroom
Thursday, September 28
Theme: Hydrocephalus Targets and Preclinical Testing
- Breakfast (Music Room)
7:00AM - Welcoming Remarks
7:45 AM
A. CONGENITAL HYDROCEPHALUS
Moderator: Ryann Fame, PhD
- Cell Reprogramming to Ependymal Lineage by GemC1/Lynkeas and McIdas
Speaker: Stavros Taraviras, PhD
8:00 AM - Genetic Targets in Hydrocephalus
Speaker: June Goto, PhD
8:25 AM - Molecular Genetics and Complex Inheritance of Congenital Hydrocephalus
Speaker: Sheng Chih (Peter) Jin, PhD
8:50 AM - Break | 9:15 AM
- Genetic Drivers of Congenital Hydrocephalus: Towards Precision Neurosurgery
Speaker: Kristopher Kahle, MD, PhD
9:45 AM - Connecting Congenital Hydrocephalus and Neural Tube Closure Through Chromatin Remodeling
Speaker: Ryann Fame, PhD
10:10 AM
A. POST-HEMORRHAGIC HYDROCEPHALUS (PHH)
Moderator: Ramin Eskandari, MD
- Choroid Plexus-Targeted NKCC1 Overexpression to Treat PHH
Speaker: Cameron Sadegh, MD, PhD
10:35 AM - Electrolyte Transporters as Drug Targets in Preclinical Studies
Speaker: Bonnie Blazer-Yost, PhD
11:00 AM - Choroid Plexus-Mediated Iron Clearance as a Treatment Strategy for PHH
Speaker: Jennifer Strahle, MD
11:25 AM - Lunch (Music Room) | 11:50 PM
- Anti-Inflammatory Targets for Treating Hydrocephalus
Speaker: Brandon Miller, MD, PhD
1:00 PM - Cerebrospinal Fluid-Based Extracellular Vesicle Signaling and Related T-Cell Activation in Post-Hemorrhagic Hydrocephalus
Speaker: Maria Garcia-Bonilla, PhD
1:25 PM - Anti-Complement Targets in Post-Hemorrhagic Hydrocephalus
Speaker: Ramin Eskandari, MD
1:50 PM - Break | 2:15 PM
A. NORMAL PRESSURE HYDROCEPHALUS (NPH)
Moderator: Abhay Moghekar, M.B.B.S, MD
- Cerebrospinal Fluid and NPH
Speaker: Abhay Moghekar, M.B.B.S
2:45 PM - Genetic Underpinnings of NPH
Speaker: Mark Johnson, MD, PhD
3:10 PM - Activating Lymphatics to Reduce Abnormal Brain Fluid Accumulation
Speaker: Young Kwon Hong, PhD
3:35 PM
B. FUTURE DIRECTIONS
- Preclinical Studies Synthesis Discussion
Moderator: Richard Keep, PhD
4:00 PM - End of program, Day 2
4:45 PM
Friday, September 29
Theme: Navigating Clinical Trials
- Breakfast (Music Room)
7:00AM
A. NAVIGATING THE CLINICAL TRIAL PROCESS
Moderator: Bonnie Blazer-Yost, PhD
- Bench to Bedside in 10 Years or Less: A Novel, Non-Surgical Therapy for PHHP
Speaker: Lauren Jantzie, PhD
8:00 AM - Initiating Clinical Trials
Speaker: Carolyn Harris, PhD
8:25 AM - Trials in Neonatal Hydrocephalus: Intraventricular Hemorrhage & PHH
Speaker: William Dawes, FRCS(SN), PhD
8:50 AM - Break | 9:15 AM
B. PARTNERING WITH OTHER SITES FOR CLINICAL TRIALS
Moderator: Bonnie Blazer-Yost, PhD
- PENS Trial
Speaker: Mark Luciano, MD, PhD
9:45 AM - Hydrocephalus Research Network (HCRN)
Speaker: John Kestle, MD
10:10 AM
10:35 AM
- Patient Perspective Panel: What Clinical Trial Measures are Important to Patients?
Panelists: Jennifer Bechard, Janet Miller, MPA and Daniela Robles, BS. - Moderator: Lauren Jantzie, PhD
Lunchtime session, 11:25 AM
Funding opportunities from the NIH and DoD with Q&A
Moderator: Carolyn Harris, PhD
Panel:
- Department of Defense (DoD)- Congressional Directed Medical Research Programs (CDMRP) Funding Opportunities
Speaker: Cecilia Dupecher, PhD, Program Manager of Peer Reviewed Medical Research Program (PRMRP) - National Institutes of Health (NIH)- Division of Rare Diseases Research Innovation, National Center for Advancing Translational Sciences
Speaker: Philip J. (P.J.) Brooks, PhD, Acting Director - National Institutes of Health (NIH)- National Institute of Neurological Disorders and Stroke (NINDS), Division of Neuroscience
Speaker: Jill Morris, PhD, Program Manager
A. MODES OF TREATMENT DELIVERY
Moderator: Alexandra Hochstetler, PhD
- Ultrasonic CSF Flow Control to Enhance Drug Delivery and Clear Pathogenic Waste
Speaker: Matine Azadian, MA
12:40 PM - Canavan Disease as a Prototype for Gene Therapy of Hydrocephalus
Speaker: Christopher Janson, MD
1:05 PM - Synthesis Discussion
Moderator: Michael Williams, MD
1:30
2:00 PM Program closing remarks, adjournment
2:00 PM | Scientific Program Adjourns