8am Breakfast
8:20am Opening and welcoming remarks
Francesco Mangano, DO, Cincinnati Children's Hospital Medical Center
Diana Gray, MA, Hydrocephalus Association
Monica Chau, PhD, Hydrocephalus Association
Session: Creating scientific consensus in the field
What are the ideal animal models and techniques to induce hydrocephalus?
9:25am Moderator: Pat McAllister, PhD, Washington University in St. Louis; Introduction to the round tables
9:30am Marc del Bigio, MD, PhD, University of Manitoba; Animal models of hydrocephalus: what is their translational utility for development of therapies?
9:45am Acquired hydrocephalus models overviews:
Pat McAllister, PhD, Washington University in St. Louis; Kaolin-induced hydrocephalus models
Jose Peiro, MD, PhD, Cincinnati Children's Hospital Medical Center; Fetal intracisternal Bioglue for a new model of obstructive hydrocephalus in large animal research
Lauren Jantzie, PhD, Johns Hopkins University; The essential role of inflammation in modeling PHHP secondary to IVH
Brandon Miller, MD, PhD, UTHealth Houston; Using blood vs. hemoglobin for IVH research
10:15am Consensus building: open discussion
10:40am Break
10:55am Genetic models overviews:
June Goto, PhD, Cincinnati Children's Hospital Medical Center; Genetic insights into models of congenital hydrocephalus
Mark Johnson, MD, PhD, UMass Memorial Health; Decoding iNPH: Mechanistic Insights from Genetically Engineered Mice
11:10am Consensus building: open discussion
Endpoint measurements in hydrocephalus studies
Moderator: Bonnie Blazer Yost, PhD, IUPUI
11:25 am Endpoint measurements
Harriet Kamendi, PhD, Kandih BioScience – FDA toxicology expectations
Charles V. Vorhees, PhD, University of Cincinnati - Behavioral testing paradigms as hydrocephalus endpoint measures
Diana Lindquist, PhD, Cincinnati Children's Hospital Medical Center - Translating MRI to the preclinical realm: advanced rodent neuroimaging for the evaluation of hydrocephalus
11:45am Consensus building: open discussion
12:10pm Lunch
