2012 Hydrocephalus Research Conference Agenda

Opportunities for Hydrocephalus Research: Pathways to Better Outcomes

Westin Hotel, Seattle, WA

Monday, July 9, 2012

07:00 Continental Breakfast and Registration

08:00 Introduction-Sponsor Acknowledgements
Dawn Mancuso, FASAE, CAE, Chief Executive Officer, Hydrocephalus Association

08:10 CAUSES OF HYDROCEPHALUS
Directors introduced by Pat McAllister, PhD; Department of Neurosurgery, Division of Pediatric Neurosurgery, University of Utah, Salt Lake City, UT

Plenary Session 1: GENETICS – Directed by Esteban Rodriguez, MD, PhD

08:10 Speaker: William B. Dobyns, MD; Seattle Children’s Research Institute & University of Washington, Seattle, WA
Title: The genetic basis of human hydrocephalus: hindbrain development, growth regulation and more

08:40 Director: Esteban Rodriguez, MD, PhD; Instituto de Histologia y Patología, Universidad Austral de Chile Valdivia, Chile
Title: Abnormal neurogenesis in foetal onset hydrocephalus in humans and animal models: opening the avenue for stem cell therapy

09:10 Speaker: Antonio J. Jimenez, PhD; Departamento de Biología Celular Genética y Fisiología, University of Malaga, Spain
Title: Repair mechanism of the disrupted ventricular zone in hydrocephalic animal models and humans

09:40 Discussion

10:00 Break

Plenary Session 2: PATHOPHYSIOLOGICAL MODIFICATIONS – Directed by Marc R. Del Bigio, MD, PhD

10:15 Director: Marc R. Del Bigio, MD, PhD; Department of Pathology & Canada Research Chair in Developmental Neuropathology, University of Manitoba, Winnipeg, Manitoba
Title: Mechanisms of cellular and axonal injury in hydrocephalus: hypoxia-ischemia in slow motion

10:45 Speaker: Stephen A. Back, MD, PhD; Departments of Pediatrics and Neurology, Oregon Health & Science University, Portland, OR
Title: Mechanisms and potential therapies for white matter injury: unexpected mechanisms of regeneration and repair

11:15 Speaker: Jerold Chun, MD, PhD; Department of Molecular Biology, Dorris Neuroscience Center, The Scripps Research Institute (TSRI), La Jolla, CA
Title: Lysophosphatidic acid (LPA) signaling in post-hemorrhagic hydrocephalus

11:45 Discussion

12:05 Lunch
Speaker: J. Gordon McComb, MD; Children’s Hospital of Los Angeles, University Children’s Medical Group, Los Angeles, CA
Title: Funding for promising aspects of hydrocephalus research by the Rudi Schulte Research Institute, Santa Barbara, CA

13:00 KEYNOTE ADDRESS
Speaker: Marc Randolph; founder & first CEO of Netflix, Santa Cruz, CA
Title: “That will never work”: the role of failure in success – the founding of Netflix

13:45 DIAGNOSIS OF HYDROCEPHALUS
Directors introduced by Samuel R. Browd, MD, PhD; Department of Neurological Surgery Seattle Children’s Hospital and the University of Washington, Seattle, WA

Plenary Session 3: BIOMARKERS– Directed by David D. Limbrick, MD, PhD

13:45 Director: David D. Limbrick, MD, PhD; St. Louis Children’s Hospital & Washington University School of Medicine, St. Louis, MO
Title: Introduction to biomarkers and brief review of post-hemorrhagic hydrocephalus

14:15 Speaker: Laurence Watkins, MD; Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London
Title: Biomarkers of NPH – molecules and other predictors of outcome

14:45 Speaker: Richard S. Morrison, PhD; Department of Neurological Surgery, Centers on Human Development and Disability & Proteomics, Intellectual and Developmental Disabilities Research Center, University of Washington School of Medicine, Seattle, WA
Title: Proteomic characterization of human ventricular cerebrospinal fluid from patients with hydrocephalus

15:15 Discussion

15:35 Break

Plenary Session 4: NEUROIMAGING- Directed by Mark Wagshul, PhD

15:50 Speaker: William G. Bradley, MD, PhD; Department of Radiology, University of California, San Diego, CA
Title: MRI of hydrocephalus with thoughts on the etiology of Idiopathic NPH

16:20 Speaker: Norman Relkin, MD, PhD; Cornell Memory Disorders Program & Departments of Clinical Neurology and Neuroscience, New York Presbyterian Hospital/Weill Cornell Medical College, New York, NY
Title: Quantitative MRI techniques for improved differential diagnosis and treatment of NPH

16:50 Director: Mark Wagshul, PhD; Department of Radiology and Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Bronx, NY
Title: Mechanisms in hydrocephalus revealed by neuroimaging

17:20 Discussion

17:40 Adjourn

 

Tuesday, July 10, 2012

07:00 Continental Breakfast and Registration

08:00 TREATMENT OF HYDROCEPHALUS – Directors introduced by Jill A. Morris, PhD; Program Director in Neurogenetics, NIH/NINDS, Bethesda, MD

Plenary Session 5: BIOENGINEERING ADVANCES- Directed by Samuel R. Browd, MD, PhD and Barry Lutz, PhD

08:00 Director: Samuel R. Browd, MD, PhD and Barry Lutz, PhD; Departments of Neurological Surgery and Bioengineering, Seattle Children’s Hospital and the University of Washington, Seattle, WA
Title: Overview of bioengineering and hydrocephalus: 50 years in 30 minutes

08:30 Speaker: Thomas J. Clement, MS; Cardiac Insight, Inc./Aqueduct Neurosciences, Inc., Seattle, Washington
Title: Roadmap for commercialization: from idea to product

09:00 Speaker: David A. Watson; Dave Watson Engineering, San Jose, California
Title: Risks and misdirection: critical areas to focus shunt technology development

09:30 Discussion

09:50 Break

Plenary Session 6: SURGICAL TREATMENTS – Directed by Jay Riva-Cambrin, MD

10:10 Director: Jay Riva-Cambrin, MD; Primary Children’s Medical Center and the University of Utah, Salt Lake City, UT
Title: Methodology for critical assessment of new techniques, the impact of surgical adjuncts in shunt placement and revisions, and novel advances in infection prevention

10:40 Speaker: Benjamin Warf, MD; Children’s Hospital Boston, Boston, MA
Title: The expanding role of combined endoscopic third ventriculostomy and choroid plexus cauterization (ETV/CPC) as the primary treatment for infant hydrocephalus

11:10 Speaker: Richard J. Edwards, MD; Department of Neurosurgery, Frenchay Hospital, Bristol, UK
Title: Strategies to reduce proximal catheter revision rates

11:40 Discussion

12:00 Lunch

13:00 OUTCOME IN HYDROCEPHALUS – directors introduced by Paul Gross; Chairman, Hydrocephalus Association

Plenary Session 7: NEUROPSYCHOLOGICAL OUTCOMES – Directed by Jack M. Fletcher, PhD

13:00 Director: Jack M. Fletcher, PhD; Department of Psychology, University of Houston, Houston, TX
Title: Hydrocephalus: Why is there variability in neuropsychological outcomes?

13:20 Speaker: Andrew Zabel, PhD; Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD
Title: Spina bifida and hydrocephalus across the lifespan: Part I – Children

13:45 Speaker: Maureen Dennis, PhD; Program in Neurosciences and Mental Health and Department of Surgery, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario
Title: Spina bifida and hydrocephalus across the lifespan: Part 2 – Adults

14:10 Speaker: Michael A. Williams, MD; The Sandra and Malcolm Berman Brain & Spine Institute, Sinai Hospital, Baltimore, MD
Title: Redeeming Salomon’s Prophesy – Reversible neuropsychological deficits of INPH

14:35 Discussion

14:50 Break

Plenary Session 8: NEUROLOGICAL OUTCOMES AND QUALITY OF LIFE – Directed by Abhaya V. Kulkarni, MD, PhD

15:10 Director: Abhaya V. Kulkarni, MD, PhD; Departments of Neurosurgery and Neurology, Toronto Hospital for Sick Children, Toronto, Ontario,
Title: Quality of life in children with hydrocephalus

15:40 Speaker: Paige T. Church; MD, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario,
Title: Troubled waters: hydrocephalus and the preterm infant

16:10 Speaker: Mohit Bhandari, MD; Canada Research Chair, Department of Surgery and Clinical Epidemiology, McMaster University, Hamilton, Ontario
Title: Advantages of evidence-based treatments: changing the philosophy of a field and identifying good research

16:40 Discussion

17:00 Adjourn

18:00 – 19:00 Reception in the Pine Room, Westin Seattle

Wednesday, July 11, 2012

07:00 Continental Breakfast

08:00 Closing Day Welcome
Dr. Richard G. Ellenbogen M.D, Professor and Chair of Neurological Surgery, Theodore S. Roberts Endowed Chair of Pediatric Neurological Surgery, University of Washington

08:05 HYDROCEPHALUS ASSOCIATION LECTURE
Speaker: Paul Gross; Chair, Board of Directors, Hydrocephalus Association
Title: Insights into NIH funding

Discussion

GROUP DISCUSSIONS

These sessions are intended to provide a consensus on each of the main focus areas with substantial audience interaction. Initial emphasis will be on the critical issues facing future research as identified in the plenary sessions.

08:45 CAUSES OF HYDROCEPHALUS

Moderator: Pat McAllister, PhD; Primary Children’s Medical Center and the University of Utah, Salt Lake City, UT
Panelists: Esteban Rodriguez, MD, PhD; William Dobyns, MD; Antonio Jimenez, PhD; Marc Del Bigio, MD, PhD; Stephen Back, MD, PhD; Jerold Chun, PhD

09:45 Break

10:00 DIAGNOSIS OF HYDROCEPHALUS

Moderator: Norman Relkin, MD, PhD; Department of Neurology, Weill Cornell Medical College, New York, NY
Panelists: David Limbrick, MD, PhD; Laurence Watkins, MD; Richard Morrison, PhD; Mark Wagshul, PhD; William Bradley, MD, PhD

11:00 TREATMENT OF HYDROCEPHALUS

Moderator: Marion (Jack) Walker, MD; Department of Neurosurgery, Division of Pediatric Neurosurgery, University of Utah, Salt Lake City, UT
Panelists: Sam Browd, MD, PhD; Tom Clement; David Watson; Jay Riva-Cambrin, MD; Benjamin Warf, MD; Richard Edwards, MD; Richard G. Ellenbogen, M.D.

12:00 Lunch

13:00 OUTCOME IN HYDROCEPHALUS

Moderator: Michael A. Williams, MD; The Sandra and Malcolm Berman Brain & Spine Institute, Sinai Hospital, Baltimore, MD
Panelists: Jack Fletcher, PhD; Andrew Zabel, PhD; Maureen Dennis, PhD; Abhaya Kulkarni, MD, PhD; Paige Church, MD

14:00 CRITICAL SUMMARY OF THE SYMPOSIUM and WHERE WE SHOULD BE IN 3 YEARS

Basic Science
Pat McAllister, PhD; Department of Neurosurgery, Division of Pediatric Neurosurgery, University of Utah, Salt Lake City, UT

Bioengineering
Samuel R. Browd, MD, PhD; Department of Neurological Surgery, Seattle Children’s Hospital and the University of Washington, Seattle, WA

Clinical
John R.W. Kestle, MD, MSc; Department of Neurosurgery, Division of Pediatric Neurosurgery, University of Utah, Salt Lake City, UT

14:45 Closing Remarks – Paul Gross

15:00 Adjourn