Mark Wagshul, PhD

2013 HA/RSRI Award Recipient

TITLE: Associate Professor
INSTITUTION: The Albert Einstein College of Medicine

STUDY TITLE: MR Elastography: A non-invasive tool for the management of shunted pediatric hydrocephalus

Overview

Dr. Wagshul is an Associate Professor in the department of radiology at Albert Einstein College of Medicine. Dr. Wagshul received a BA in physics from Rutgers University and a PhD in physics from Harvard University. He completed a postdoctoral fellowship at the National Institute for Standards and Technology. He received the 2013 HA/Rudi Schulte Research Institute research award for his study, MR Elastography: A non-invasive tool for the management of shunted pediatric hydrocephalus.

His proposed project utilizes the noninvasive MRI-based technique, magnetic resonance elastography (MRE) to determine the role which brain compliance plays in pediatric hydrocephalus. The overall goal of the project is to improve the knowledge of the role brain elastance plays in hydrocephalus, which will hopefully drive the development of alternative treatments for split ventricle.

Research Topics

Quantitative flow imaging, hydrocephalus, animal models of disease, multiphoton confocal microscopy, MS, MR spectroscopy, diffusion tensor imaging, volumetric analysis, MRI pulse sequence development

Publications

Sandler AL, Goodrich JT, Wagshul ME, Abbott R.
Comment on the Article by Hart et al. Entitled ‘Combined Intracranial Pressure Monitoring and Cerebrospinal Fluid Infusion Study to Guide Management of Slit Ventricle Syndrome’
Pediatr Neurosurg. 2014 Jul 3.

Cole PD, Vijayanathan V, Ali NF, Wagshul ME, Tanenbaum EJ, Price J, Dalal V, Gulinello ME.
Memantine protects rats treated with intrathecal methotrexate from developing spatial memory deficits.
Clin Cancer Res. 2013 Aug 15;19(16):4446-54.

L.K. Vingara, H.J. Yu, M.E. Wagshul, D. Serafin, C. Christodoulou, I. Pelczer, L.B. Krupp, M Maletić-Savatić,
Metabolomics approach to human brain spectroscopy identifies associations between clinical features and the frontal lobe metabolome in multiple sclerosis
Neuroimage. 2013 Nov 15;82:586-94.

R.A. Bhadelia, Neel Madan, Y. Zhang, M.E. Wagshul, C. Heilman, J.P. Butler, S. Patz,
Physiology-based MRI Assessment of CSF Flow at the Foramen Magnum with a Valsalva Maneuver,
AJNR Am J Neuroradiol. 2013 Sep;34(9):1857-62

M.E. Wagshul, S. Sin, K. Shifteh, M.L. Lipton, R. Arens,
Novel Retrospective, Respiratory-Gating Method Enables 3D, High Resolution, Dynamic Imaging of the Upper Airway during Tidal Breathing
Magn Reson Med. 2013 Dec;70(6):1580-90

H.J Yu, C. Christodoulou, V. Bhise, D. Greenblatt, Y. Patel, D. Serafin, M. Maletic-Savatic, L.B. Krupp, M.E. Wagshul,
Multiple white matter tract abnormalities underlie cognitive impairment in RRMS
Neuroimage, 59:3713-3722 (2012).

S. Rashid, J.P. McAllister, Y. Yu, M.E. Wagshul,
Neocortical capillary flow pulsatility is not elevated in experimental communicating hydrocephalus
J Cereb Blood Flow Metab, 32:318-329 (2012).

M.E. Wagshul, P.K. Eide, J.R. Madsen,
The Pulsating Brain: A review of experimental and clinical studies of intracranial pulsatility
Fluid and Barriers of the CNS, 8:5 (2011).

G. Nagra, M.E. Wagshul, S. Rashid, J. Li, J.P. McAllister, M. Johnston,
Elevated CSF outflow resistance associated with impaired lymphatic absorption in a rat model of kaolin induced communicating hydrocephalus
CSF Res, 7:4 (2010).

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