What’s the Matter?

Tags: , , , , ,

Injury to Brain MatterWhite vs. Grey Matter Injury

Brain damage is often described as either a white or grey matter injury, but what is the difference?

White Matter Injuries

White matter injuries occur when white matter tracts (bundles of myelinated axons) are damaged. Damage essentially cuts off or limits communication between areas of grey matter (neuron cell bodies and dendrites, the neuropil, glial cells, and capillaries). Perhaps the easiest example to envision is a spinal cord injury. The outside of the spinal cord is composed of large white matter tracts. Transecting or compressing these tracts can lead to paralysis because information from the brain’s motor cortex (grey matter) can no longer reach the spinal cord and muscles. White matter tracts relaying sensory information from the muscles and skin to the brain can also be lost. In this case, the patient may not be able to feel an ice cube placed on his or her skin.

White matter injuries are very serious, but, depending on the type and extent of the injury, extensive recovery may occur. As long as the neuron cell bodies remain healthy, axons can regrow and slowly repair themselves. Functional recovery may also occur if the information can be transmitted through an alternative route. In many cases, this occurs through the strengthening of weak connections that already exist.

Grey Matter Injuries

Neuronal death is at the heart of grey matter injury. The neuron cell bodies are responsible for keeping the entire neuron alive and healthy and that takes a lot of energy. Grey matter is therefore very susceptible to injury when oxygen levels are low (hypoxia) such as during an ischemic event. Damage also occurs when the local environment changes such as during an intracerebral hemorrhage or when physical damage occurs. Damaged neurons and glia also release factors that can increase the effect of the injury. In many cases, the initial damage causes a series of downstream effects that can initiate apoptosis (programmed cell death). Once damage has occurred, the cell cannot support its axons or dendrites and the entire cell dies. This is especially true in neurons that have large cell bodies and long axons. In contrast, after a white matter injury, a healthy cell body may be able to repair the damaged axon.

Like white matter injuries, the type and extent of the injury largely dictates recovery. Young infants and children often have better outcomes than adults since their neural systems are still developing and more adaptable. Targeted rehabilitation training can also improve functional outcomes. For instance, after selective damage to the motor cortex, fine finger movements can be improved when the rehabilitative training results in an expansion of the finger motor representation within the motor cortex. In other words, nearby neurons can begin to take over the functions of the damaged neurons.

White and Grey Matter Interactions

Although white and grey matter injuries are often presented as separate entities, it is hard to have one without the other. This is because (1) many injuries simply involve both grey and white matter areas, (2) a single neuron can have its cell body and dendrites in the grey matter and an axon in the white matter, and (3) because neurons depend on their interactions with other neurons.

White matter damage can cause a great deal of stress and increase the energy demands on the neuron. In some cases, the neuron will not be able to meet the energy demands and the entire neuron will die (cell body, axon, and dendrites). This often starts with retraction of the injured axon. On the other end, the grey matter targeted by that axon (i.e. the post-synaptic neurons) can shrink and die from inactivity or be taken over by other functions (i.e. innervated by other neurons). Grey matter near the site of white matter injury can also be damaged by factors released from damaged axons and vice versa.

15 Comments for : What’s the Matter?
    • Deinea
    • October 19, 2020

    would this be something to worry about in the ER if someone came in with headache frontal lobe and stiff neck, blurry vision and nose bleed?
    or would they say your CT was normal

  1. Reply

    I had a brain scan and the doctor showed it to and I have white matter covering my brain and some spots inside my brain. The doctor said it was from my headaches but I asked for the brain scan cause I was having memory loss.

  2. Reply

    Thank you for the information. More specifically: (1) What does it mean if there is severe white matter reduction, but the cortex is intact? (2) Is the white matter (axons) still there, but only reduced in size, or does the body have to regenerate axons from the cortex (cell body)?

    • Yolanda Steward
    • June 17, 2020

    Just concerned I have white matters just found out iam pretty worried should I be ?

    • Bello jemilat
    • April 6, 2020

    Can the grey matter of the brain be repaired or not when damaged.

  3. Reply

    Yes, Thank You very much for this information ! I just recently found out that I have the “Scattered” White Matter Brain Disease and I am “trying to accept it”? Yes I have had back, neck, and shoulder injuries ! I have had concussions too one severe ! It is a lot to deal with especially following a stroke ! Thank You, Sincerely Bob Singley

    • Ethel
    • December 2, 2019

    Where can I schedule a visit with a doctor who specializes in white matter disease.

    • Robin Hartley
    • November 18, 2019

    I have Brain Injury and all I see is grey out my eyes I feel I’m loosing more and more eye sight everyday

    • Kevin
    • August 23, 2019

    Can someone please help I had a tbi fell 40 feet from scaffolding and was unconscious for 5 minutes, I was diagnosed with post concussion syndrome after and I have not been the same since, it’s been over 14 months since the injury and I still have a lot of problems , mri showed white matter changes

  4. Reply

    My MRI shows hyper intense focus left frontal white matter after a severe whiplash injury. I have cognitive problems and memory deficits. Isn’t this from the accident?

    • Francesca
    • March 16, 2018

    Can cell repair be an option in repairing the white an grey matter?

      • sophia summers
      • November 28, 2018

      Yes some meditation and yoga forms help as do action video games. Read journal articles

    • Ricky
    • September 30, 2016

    So what happens when there is severe damage to the grey matter because a lack of oxygen and blood caused the grey matter to die in a dispersed fashion?

      • Georgia Banning Welch Simon
      • March 21, 2018

      I would like to know this also? My 38y old Son has recently had a problem l(irreversible damage to Grey Matter) due to lack of oxygen!

  5. Reply

    Hello my name is Shawntel Pitts. I have a brain injury called adem. For short. And I tell my self each day I’m BETTER. When it’s clear that I am NOT. I was getting a CHECK for my self and two CHILDREN. I have tried to work but just kept right on getting fired. My mom was my over seer. I made a big mistake telling my doctor to cut my CHECK for NOTHING is there anyway to get it back.

Leave a Comment

Change this in Theme Options
Change this in Theme Options