Mohammed Alshareef, MD

2020 Resident’s Prize in Hydrocephalus

PROJECT TITLE: Complement Activation Leads to Worse Cognitive Outcomes Following Germinal Matrix
Hemorrhage in a Chronic Mouse Model

Mohammed Alshareef is a 6th year neurological surgery resident at the Medical University of South Carolina (MUSC). He obtained his biomedical engineering degree at the University of South Carolina (USC) and medical degree from MUSC. Mohammed has focused his efforts to study complement activation in germinal matrix hemorrhage (GMH) and post-hemorrhagic hydrocephalus (PHH) in neonatal mice; he was awarded the 2020 NREF grant to continue his work. He and his team have developed a novel GMH model for testing of complement inhibitors and exploring the natural history of post-hemorrhagic sequela, a project with a high translational potential. Clinically, he has worked on multiple clinical projects related to pediatric neurosurgery patients, including early intervention in post-hemorrhagic hydrocephalus and risk of requiring ventriculoperitoneal shunting. Following residency, Mohammed will pursue a pediatric neurosurgery fellowship and a subsequent pediatric spine fellowship.

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