2009 Mentored Young Investigator Recipient
TITLE: Research Associate
INSTITUTION: The Scripps Research Institute
At the time of his grant, Yun Yung was a graduate student at the Scripps Research Institute. In 2010, Yun completed his dissertation and has since been promoted from a postdoctoral fellow to a research associate. Dr. Yung received an A.B. in neuroscience from the University of California, Berkeley and a Ph.D. in neuroscience from the University of California, San Diego.
STUDY TITLE: LPA signaling in hydrocephalus
MENTOR: Jerold Chun, MD, PhD
Dr. Yung’s study aimed to determine the role of the small lipid, lysophosphatidic acid or LPA, that has been identified as a cause of fetal hydrocephalus (FH) in mice. The study explored whether there is a critical period during brain development in which intracranial bleeding is likely to lead to hydrocephalus. In addition, the study tested whether pharmacological blockade of LPA receptors in the brain can ameliorate FH. The researchers were able to show that FH occurred mainly through LPA1 signaling pathway. The researchers propose that the LPA1 signaling pathway is a molecular mechanism that may account for the observation linking prenatal bleeding and FH. They hypothesize that high concentration of LPA leads to the activation of LPA receptors expressed by neural progenitor cells, which in turn activate other intracellular signaling to produce disorganization and thinning of the cortical layers and, ultimately, FH.
Molecular Biology, Methods, Cell Biology, Cancer Biology, Neuroscience, Pharmacology, Artificial Intelligence, Hydrocephalus
2011 Nature Lipid Pathways
2009 Society for Neuroscience
2009 Federation of American Societies for Experimental Biology
Selected hydrocephalus-related publications
Yung YC, Muto T, Lin M-E, Noguchi K, Rivera RR, Kingbury MA, Chun J.
Lysophosphatidic Acid Signaling May Initiate Fetal Hydrocephalus.
Science Translational Medicine 2011; 3(99):99ra87.
Reviews & Book Chapters:
Yung YC, Stoddard NC, Chun J.
LPA receptor signaling: pharmacology, physiology, and pathophysiology.
J Lipid Res. 2014 Mar 18;55(7):1192-1214.
Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J.
LPA Receptors: Subtypes and biological actions.
Annu Rev Pharmacol Toxicol. 2010; 50:157-86.
Teo ST, Yung YC, Herr D, Chun J.
Lysophosphatidic Acid in Vascular Development and Disease.
IUBMB Life. 2009; 61(8):791-799.