2009 Mentored Young Investigator Recipient
TITLE: Clinical Instructor of Neurosurgery
INSTITUTION: Stanford and Lucile Packard Children’s Hospital
Dr. Eskandari was a resident neurosurgeon at the University of Utah at the time of his award. He is currently a clinical instructor and neurosurgeon at Stanford and Lucile Packard Children’s Hospital. He received a B.S. in biology from the University of Michigan, an M.S. in medical sciences and an M.D. from Wayne State University.
STUDY TITLE: Early versus late CSF drainage treatment in experimental neonatal hydrocephalus
MENTOR: James P (Pat) McAllister, PhD
The investigators hypothesize that delayed reservoir placement for treatment of neonatal hydrocephalus has consequences that can be measured through MRI-imaging, CSF evaluation, neurological assessment, and examination of brain tissue. Initial results indicated that it did not change the course of ventriculomegaly whether the animals had early or late placement. Another result indicated that tapping the reservoir based on neurological deficit (current practice tends to favor waiting for signs of elevated ICP and neurologic deficit before treatment with temporary CSF drainage) does not halt progression of ventricular enlargement and that neurologic deficit correlates strongly with ventricular enlargement.
Selected hydrocephalus-related publications
Eskandari R, Abdullah O, Mason C, Lloyd KE, Oeschle AN, McAllister JP 2nd.
Differential vulnerability of white matter structures to experimental infantile hydrocephalus detected by diffusion tensor imaging.
Childs Nerv Syst. 2014 Jul 29.
Eskandari R, Filtz MR, Davis GE, Hoesch RE.
Effective treatment of refractory intracranial hypertension after traumatic brain injury with repeated boluses of 14.6% hypertonic saline.
J Neurosurg. 2013 Aug;119(2):338-46.
Eskandari R, Packer M, Burdett EC, McAllister JP 2nd.
Effect of delayed intermittent ventricular drainage on ventriculomegaly and neurological deficits in experimental neonatal hydrocephalus.
Childs Nerv Syst. 28:1849-1861. 2012
La Barge DV 3rd, Bishop FS, Stevens EA, Eskandari R, Schmidt RH, Skalabrin EJ, Ng PP.
Intrasinus catheter-directed heparin infusion in the treatment of dural venous sinus thrombosis.
AJNR Am J Neuroradiol. Jul 17. 2009
Eskandari R, Amini A, Yonemura KS, Couldwell WT.
The use of the Olympus EndoArm for spinal and skullbased transsphenoidal neurosurgery.
Minim Invasive Neurosurg. 51(6):370-2. 2008
Shprecher D, Frech T, Chin S, Eskandari R, Steffens J.
Progressive multifocal leucoencephalopathy associated with lupus and methotrexate overdose.
Lupus. 17(11):1029-32. 2008.
Eskandari R, McAllister JP, Miller JM, Ding Y, Ham SD, Shearer DM, Way JS.
Effects of hydrocephalus and ventriculoperitoneal shunting on afferent and efferent connections of the feline sensorimotor cortex.
Journal of Neurosurgery (Pediatrics 2) 101:196-210. 2004.
Vazquez DM, Eskandari R, Phelka A, Lopez JF.
Impact of maternal deprivation on brain corticotropin-releasing hormone circuits: prevention of CRH receptor-2 mRNA changes by desipramine treatment.
Neuropsychopharmacology. May; 28(5):898-909. 2003.