Joon W. (Simon) Shim, PhD

2009 Mentored Young Investigator Recipient

TITLE: Visiting Faculty
INSTITUTION: Indiana University-Purdue University Indianapolis


During the time of his grant, Dr. Shim was a postdoctoral fellow at Children’s Hospital of Boston. From Boston, Dr. Shim moved to Indianapolis where he was a postdoctoral fellow and then a research assistant professor in bioengineering at IUPUI. In 2014, Dr. Shim became a visiting faculty member at IUPUI and is still conducting hydrocephalus research.  Dr. Shim received a B.S. in mechanical engineering and an M.E. in thermo fluid mechanics from Soongsil University Seould South Korea, an M.S. in biomedical engineering from Rensselaer Polytechnic Institute, and a Ph.D. in biomedical engineering from Mississippi State University.

STUDY TITLE: The role of angiogenesis in hydrocephalus

MENTOR: Joseph Madsen, MD

Angiogenesis is the process of forming new blood vessels.  It is essential for development and repair within the body. However, as a powerful physiological process, it can also, for example, be the transition from a tumor being benign to malignant. For this reason, angiogenesis has been linked to diseases including cancer, autoimmune diseases, age-related macular degeneration and atherosclerosis.  The most common pro-angiogenic factor is vascular endothelial growth factors (VEGF).  Dr. Shim’s study had three main aims: (1) quantify the level of VEGF in hydrocephalic patients; (2) determine if infusion of VEGF into mice causes hydrocephalus; and (3) determine if infusion of anti-VEGF antibodies (bevacizumab) blocked ventriculomegaly.

Research Topics

Neuroscience, Neurosurgery, Anti-angiogenesis, Therapy, Hydrocephalus, Animal Models, Ependymal, Neural Stem Cells


2014 Invited Talk: Cincinnati Children’s Hospital Medical Center
2014 Invited Talk: University of Notre  Dame
2014 Invited Talk: University of New Haven
2014 Invited Talk: Florida Technical College
2013 Invited Talk: University of Cincinnati
2013 Annual Conference of the  Orthopaedic Research Society
2013 Invited Talk: Trine University
2012 Invited Talk: Harvard University
2010 National Conference on Hydrocephalus
2010 Annual Meeting of the American Society of Pediatric Neurosurgeons
2009 Annual Meeting of the AANS/CNS Section on Pediatric Neurosurgery


Selected hydrocephalus-related publications

Shim JW, Sandlund J., Madsen JR.
VEGF: A Potential Target for Hydrocephalus.
2014 Cell Tissue Res.Accepted Jul.

Shim JW.
Drug Discovery Research for Hydrocephalus [Editorial].
2014 JSM Neurosurg Spine 2(1): 1009.

Shim JW, Dodge TR, Hammond MA, Wallace JM, Zhou FC, Yokota H.
Physical Weight Loading Induces Expression of Tryptophan Hydroxylase 2 in the Brain Stem.
2014 PLoS ONE 9(1): e85095. doi:10.1371/journal.pone.0085095

Shim JW, Sandlund J, Han CH, Hameed MQ, Connors S, Klagsbrun M, Madsen JR, Irwin N.
VEGF, which is elevated in the CSF of patients with hydrocephalus, causes ventriculomegaly and ependymal changes in rats.
Exp Neurol. 2013 Sep;247:703-9

Shim J.W., Dudley A, Klagsbrun M, Smith S, Madsen J.R.
Effect of rhHB-EGF on the expression of hydrocephalus-related genes in vitro.
Cerebrospinal Fluid Research. 2009 6(Suppl1):S5.

Madsen J.R., Shim J.W., Abazi G., Fleming L., Fernholz B., Connors S., Folkman J.
VEGF-A is elevated in CSF of pediatric patients undergoing surgery for hydrocephalus.
Cerebrospinal Fluid Research. 2009 6(Suppl 1):S13.

Shim J.W., Wise D.A., Elder S.H.
Effect of Cytoskeletal Disruption on Mechanotransduction of Hydrostatic Pressure by C3H10T1/2 Murine Fibroblasts.
The Open Orthopaedics Journal, 2008, 2: 155-162.

Elder S.H., Shim J.W., Borazjani A., Robertson H.M., Smith K.E., Warnock J.N.
Influence of hydrostatic and distortional stress on chondroinduction.
Biorhelogy, 2008, 45(3-4):479-486.




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