2009 Mentored Young Investigator Recipient
TITLE: Assistant Staff
INSTITUTION: Cleveland Clinic
At the time of his award, Abhishek Deshpande was a PhD candidate in cellular and molecular biology. In 2010, Dr. Deshpande began a postdoctoral fellowship in the Department of Pediatric Neurosurgery, Cleveland Clinic. Dr. Deshpande is currently an Assistant Staff at Cleveland Clinic, Department of Medicine with a joint appointment in the Department of Infectious Diseases. Dr. Deshpande earned his medical degree from Manipal University, India and his PhD in cellular and molecular biology from Kent State University/Cleveland Clinic Collaborative Program.
STUDY TITLE: Effects of VEGF agonist (rVEGF) and VEGF antagonist (Bevacizumab) treatment on cerebrovascular density and permeability, and learning in a kaolin model of hydrocephalus
MENTOR: Mark Luciano, MD, PhD
Chronic adult hydrocephalus (CH) is a leading cause of preventable neurological injury. Although the pathophysiology, diagnosis, and treatments of CH are poorly understood, decreased oxygen in the brain through blood vessel compression and formation of new vessels may play a role in injury and recovery. We hypothesize that treatment with the drug bevacizumab will inhibit new vessel formation and thereby limit vessel permeability and fluid exchange in the cranium.
Clinically oriented research, infectious diseases, neurosciences, medical statistics.
2011 11th National Hydrocephalus Conference
2011 Society for Research into Hydrocephalus and Spina Bifida
2010 Society for Neuroscience Annual Meeting
2010 Research Showcase, Case Western Reserve University
2009 Society for Neuroscience Annual Meeting
2008 Society for Neuroscience Annual Meeting
2007 Society for Research into Hydrocephalus and Spina Bifida
2006 Congress of Neurologic Surgeons
2006 Society for Research into Hydrocephalus and Spina Bifida
2005 Society for Neuroscience Annual Meeting
Selected hydrocephalus-related publications
Yang J, Dombrowski SM, Krishnan C, Krajcir N, Deshpande A, El-Khoury S, Guruprakash DK, Luciano MG.
Vascular endothelial growth factor in the CSF of elderly patients with ventriculomegaly: Variability, periodicity and levels in drainage responders and non-responders.
Clin Neurol Neurosurg. 2013 Sep;115(9):1729-34.
Yang J, Dombrowski SM, Deshpande A, Krajcir N, El-Khoury S, Krishnan C, Luciano MG.
Stability analysis of vascular endothelial growth factor in cerebrospinal fluid.
Neurochem Res. 2011 Nov;36(11):1947-54.
Yang J, Dombrowski S, Deshpande A, Krajcir N, Luciano MG. .
VEGF/VEGFR-2 changes in frontal cortex, choroid plexus, and CSF after chronic obstructive hydrocephalus.
J Neurol Sci. 2010 Sep 15;296(1-2):39-46.
Despande A, Dombrowski SM, Leichliter A, Krajcir N, Zingales N, Inoue M, Schenk S, Fukamachi K, Luciano MG.
Dissociation between vascular endothelial growth factor receptor-2 and blood vessel density in the caudate nucleus after chronic hydrocephalus.
J Cereb Blood Flow Metab, 1-10. 2009
Dombrowski SM, Deshpande A, Dingwall C, Leichliter A, Leibson Z Luciano MG.
Chronic hydrocephalus-induced hypoxia: increased expression of VEGFR-2+ and blood vessel density in hippocampus.
Neuroscience 152(2):346-99. 2008
Ford PJ, Deshpande A.
“Ethics: Life and death choices in traumatic brain injury.”
Brain Trauma and Critical Care. eds. Jallo J, Loftus CM. Thieme, 2009