James P. (Pat) McAllister, PhD

2011 Established Investigator

TITLE: Professor of Neurosurgery and Director of Basic Hydrocephalus Research
INSTITUTION: The University of Utah

STUDY TITLE: Novel neurobiological interventions for the treatment of hydrocephalus


Dr. McAllister is a professor of neurosurgery and the Director of Basic Hydrocephalus Research at the University of Utah. He received a B.A. in biology from Earlham College and a PhD in neurobiology from Purdue University.  He was awarded an Established Investigator award in 2010 for his study, Novel neurobiological interventions for the treatment of hydrocephalus.

Dr. McAllister’s study investigates the abnormal blockage of cerebrospinal fluid flow. The study uses animal models and patient CSF to increase our understanding of the damage that occurs in the hydrocephalic brain.  Using this information can help advance the development of novel transplantation therapies.

Research Topics

Pathophysiology of hydrocephalus, neuroprotection and recovery of neural function, biomedical engineering and biocompatibility of neural implants


Botfield H, Gonzalez AM, Abdullah O, Skjolding AD, Berry M, McAllister JP 2nd, Logan A. Decorin prevents the development of juvenile communicating hydrocephalus. Brain. 2013 Sep;136(Pt 9):2842-58. doi: 10.1093/brain/awt203.

Simon TD, Van Yserloo B, Nelson K, Gillespie D, Jensen R, McAllister JP 2nd, Riva-Cambrin J, Stockmann C, Daly JA, Blaschke AJ. Use of quantitative 16S rRNA PCR to determine bacterial load does not augment conventional cerebrospinal fluid (CSF) cultures among children undergoing treatment for CSF shunt infection. Diagn Microbiol Infect Dis. 2013 Aug 13

Ortloff AR, Vío K, Guerra M, Jaramillo K, Kaehne T, Jones H, McAllister JP 2nd, Rodríguez E. Role of the subcommissural organ in the pathogenesis of congenital hydrocephalus in the HTx rat. Cell Tissue Res. 2013 Jun;352(3):707-25.

McAllister JP 2nd. Pathophysiology of congenital and neonatal hydrocephalus. Semin Fetal Neonatal Med. 2012 Oct;17(5):285-94.

Eskandari R, Packer M, Burdett EC, McAllister JP 2nd. Effect of delayed intermittent ventricular drainage on ventriculomegaly and neurological deficits in experimental neonatal hydrocephalus. Childs Nerv Syst. 2012 Nov;28(11):1849-61.

Harris CA, McAllister JP 2nd. What we should know about the cellular and tissue response causing catheter obstruction in the treatment of hydrocephalus. Neurosurgery. 2012 Jun;70(6):1589-601; discussion 1601-2.

Yuan W, McAllister JP 2nd, Lindquist DM, Gill N, Holland SK, Henkel D, Rajagopal A, Mangano FT. Diffusion tensor imaging of white matter injury in a rat model of infantile hydrocephalus. Childs Nerv Syst. 2012 Jan;28(1):47-54.



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