David Limbrick, MD, PhD

2018 Posthemorrhagic Hydrocephalus Discovery Science Award

INSTITUTION: Washington University in St. Louis

STUDY TITLE: Pharmacological Prevention of PHH of Prematurity


Dr. David Limbrick received his MD and PhD at the Medical College of Virginia, Virginia Commonwealth University. He is now a Professor of Neurological Surgery and Pediatrics and the Neurosurgeon-in-Chief at St. Louis Children’s Hospital. Dr. Limbrick is a principal investigator for the HA-funded Hydrocephalus Clinical Research Network (HCRN.org) and runs a basic science laboratory focused on hydrocephalus and other cerebrospinal fluid (CSF) disorders.

This study, “ADAM 10 Inhibition: a novel therapeutic strategy for posthemorrhagic hydrocephalus of prematurity,” will investigate how blood damages the cells that line the ventricles and test if a specific drug can stop this damage and prevent hydrocephalus. This work builds on previous findings that the proteins that hold these cells together are damaged in many forms of hydrocephalus and may actually cause the hydrocephalus. If this drug can stop that damage from occurring, we may be able to stop hydrocephalus from developing after a brain bleed.

For more information on cell junctions and their role in posthemorrhagic hydrocephalus read these blogs!

Research 101: Junction, Junction, What’s Your Function?

New Theories in Posthemorrhagic Hydrocephalus

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