MYI Investigators

MYI awardees presented at the 11th National Conference on Hydrocephalus

Hydrocephalus Association Research Initiative

In July 2009, the Hydrocephalus Association (HA) announced a Request for Applications (RFA) for a Mentored Young Investigator (MYI) Research Award. Each application was evaluated by the HA Scientific and Medical Review Committee (SMRC) based upon the following criteria: Mentor and Training Environment; Likelihood that the Proposed Project will Advance Hydrocephalus Treatment/Cure; Scientific Merit of the Research Proposal; and Applicant Training and Career Potential.


TITLE:
Augurin is a novel choroid plexus-derived peptide hormone that regulates CSF formation by controlling epithelial cell homeostasis

DESCRIPTION:
This research project will determine the function and mechanism of action of a newly discovered hormone called augurin in regulating fluid balance in the CNS with the long term goal of modulating its expression and controlling its activity to treat hydrocephalus pharmacologically.

Dr. Sonia Podvin

Dr. Podvin

INVESTIGATOR:
Sonia Podvin, PhD

Dr. Podvin is a post-doctoral fellow in Neuroendocrinology.

MENTOR:
Andrew Baird, PhD

INSTITUTION:
University of California, San Diego, School of Medicine


TITLE:
In children presenting with hydrocephalus, is ventricular size associated with neuropsychological outcomes: Proposal for a phase II clinical study.

DESCRIPTION:
This multi-center research study will examine the relationship between ventricle size and neuropsychological testing 6 months after treatment for hydrocephalus. In addition, the investigators will evaluate the validity of the current neuropsychological tests employed for patients with hydrocephalus and recommend tests for future use.

jay riva-cambrin, MD

Dr. Riva-Cambrin

INVESTIGATOR:
Jay Riva-Cambrin, MD, MSc

Dr. Cambrin is a pediatric neurosurgeon.

MENTOR:
John Kestle, MD, MSc

INSTITUTION:
University of Utah


TITLE:
Quantitative Measurement of Ventricular Volume and Cortical Atrophy
to Improve Diagnosis of Normal Pressure Hydrocephalus

DESCRIPTION:
This study evaluates whether obtaining new information from MRI
scans can improve the diagnosis of adult Normal Pressure Hydrocephalus (NPH).

INVESTIGATOR:
Dana W. Moore, PhD.

Dr. Dana Moore

Dr. Moore

Dr. Moore is an accomplished post-doctoral fellow in Neuropsychology and faculty
position candidate. She will apply her considerable clinical experience with
patients suffering from head trauma and Alzheimer’s Disease to neuro-imaging in
hydrocephalus.

MENTOR:
Norman R. Relkin, MD, PhD

INSTITUTION:
Weill Cornell Medical College of Cornell University
The Weill Cornell Medical College, located in New York City, was founded in 1898
and has been affiliated with (what is now) New York-Presbyterian Hospital since
1927. It is among the top-ranked clinical and medical research centers in the
country.


TITLE:
Lysophosphatidic acid (LPA) Signaling in Hydrocephalus

DESCRIPTION:
The investigators will study the role of a small lipid (called LPA) that has recently been identified as a cause of fetal hydrocephalus in mice, exploring whether there is a critical period during brain development in which intracranial bleeding is likely to lead to hydrocephalus.

INVESTIGATOR:
Yun C. Yung

Yun C. Yung

Mr. Yung

Mr. Yung is a doctoral student in Molecular Biology. He was the recipient of a prestigious National Science Foundation fellowship and is known for his ability to collaborate with both clinicians and basic scientists. He brings a varied research background in cancer and neuroscience to his exploration of a cause of fetal hydrocephalus.

MENTOR:
Jerold Chun, MD, PhD

INSTITUTION:
The Scripps Research Institute

The Scripps Research Institute, located in southern California, is one of the country’s largest, private, non-profit research organizations. The Institute has become internationally recognized for its basic research into immunology, molecular and cellular biology, chemistry, neurosciences, autoimmune diseases, cardiovascular diseases, virology and synthetic vaccine development.


TITLE:
Early versus Late CSF Drainage Treatment in Experimental Neonatal Hydrocephalus

DESCRIPTION:
The investigators hypothesize that delayed reservoir placement for treatment of neonatal hydrocephalus has consequences that can be measured through MRI-imaging, CSF evaluation, neurological assessment and examination of brain tissue.

INVESTIGATOR:
Ramin Eskandari, MD

Ramin Eskandari, MD

Dr. Eskandari

Dr. Eskandari is a 4th year resident physician in Pediatric Neurosurgery. He brings basic research experience in both neuroendocrinology and hydrocephalus and a number of publications to this project. He plans to become an academic pediatric neurosurgeon.

MENTOR:
Pat McAllister, PhD

INSTITUTION:
University of Utah

The University of Utah in Salt Lake City, is ranked among the top 30 public research universities in the nation with particular distinctions in medicine and genetics. As a result of benchmarking research, the university ranks 15th in the nation for significant awards to faculty for research efforts.


TITLE:
The role of angiogenesis in hydrocephalus

DESCRIPTION:
In this project, the vascular biology of hydrocephalus is highlighted proposing that hydrocephalus might be mitigated by a pharmacological approach.

INVESTIGATOR:
Joon W. Shim, PhD

Dr. Joon Shim

Dr. Shim

Dr Shim is a post-doctoral research fellow in Neurosurgery. He brings biomedical engineering expertise to his study of the tissue response of the brain to hydrocephalus. Dr. Shim is pursuing an academic career in hydrocephalus research.

MENTOR:
Joseph R. Madsen, MD

INSTITUTION:
Children’s Hospital Boston

Children’s Hospital Boston is home to the world’s largest and most active research enterprise at a pediatric center. Staffed by Harvard Medical School faculty members, the research mission of Children’s Hospital encompasses basic research, clinical research, community service programs and the postdoctoral training of new scientists.


TITLE:
Effects of VEGF agonist (rVEGF) and VEGF antagonist (Bevacizumab) treatment on cerebrovascular density and permeability, and learning in a kaolin model of hydrocephalus

DESCRIPTION:
This research project will employ an established animal model of hydrocephalus to test whether treatment with pharmacological agents can effect the development and progression of chronic adult hydrocephalus.

INVESTIGATOR:
Abhishek Deshpande, MD

Dr. Abhishek Deshpande

Dr. Deshpande

Dr. Deshpande is a physician and doctoral candidate in Neurosurgery who seeks to integrate clinical and laboratory expertise in the research setting. His goal is to become a physician researcher in neurological sciences with a focus on hydrocephalus.

MENTOR:
Mark Luciano, MD, PhD

INSTITUTION:
Cleveland Clinic

The multidisciplinary Cleveland Clinic Neurological Institute combines all physicians and other healthcare providers in neurology, neurosurgery, neuroradiology, the behavioral sciences and nursing who treat adult and pediatric patients with neurological disorders. U.S.News & World Report’s “America’s Best Hospitals” survey has consistently ranked the Neurology and Neurosurgery programs among the top 10 in the nation and the best in Ohio.

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